UNC0379 trifluoroacetate salt is a substrate-competitive inhibitor of the lysine methyltransferase SETD8, the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20). HK420 methylation has been implicated in the regulation of a variety of biological processes including the DNA damage response. UNC0379 is selective for SETD8 over 15 other methyltransferases, with an IC50 of 7.3 μM for SETD8 compared to IC50 vlaues over 100 μM for other methyltransferases. References:

纯度：≥98%

CAS：1620401-83-3