| CAS NO: | 541-46-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| Molecular Weight (MW) | 101.15 |
|---|---|
| Formula | C5H11NO |
| CAS No. | 541-46-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 20 mg/mL (197.7 mM) |
| Water: <1 mg/mL | |
| Ethanol: 20 mg/mL (197.7 mM) | |
| Other info | Chemical Name: 3-Methylbutanamide InChi Key: SANOUVWGPVYVAV-UHFFFAOYSA-N InChi Code: InChI=1S/C5H11NO/c1-4(2)3-5(6)7/h4H,3H2,1-2H3,(H2,6,7) SMILES Code: CC(C)CC(N)=O |
| Synonyms | 3-Methylbutanamide; NPS-1776; Isovaleramide; NPS 1776; NPS1776; |
| In Vitro | In vitro activity: Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases. It is isolated from the most active fraction of Valeriana pavonii. Isovaleramide (300 μM) exhibits a 42% of inhibition of the binding of 3H-FNZ to its sites in the in vitro assay. Isovaleramide is without effect at concentrations up to 1000 μM in a variety of in vitro neurotransmitter binding or uptake assays, suggesting that its action does not involve a direct receptor-mediated effect at those systems studied. Isovaleramide (0.15%) induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3. |
|---|---|
| In Vivo | Isovaleramide (100 mg/Kg, p.o) evidences a 90% index protection against the maximal electroshock seizure in mice (MES). Isovaleramide produces a consistent pattern of signs at relatively high doses in extensive safety studies in rats, rabbits, and dogs. Isovaleramide shows a significantly lower potential for reproductive toxicity than VPA in several reproductive toxicity studies conducted in mice, rats and rabbits. |
| Animal model | Mice |
| Formulation & Dosage | 100 mg/Kg, p.o |
| References | Biomedica. 2010 Apr-Jun;30(2):245-50; Epilepsy Res. 2004 Sep-Oct;61(1-3):1-48. |
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