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Ammonium Glycyrrhizinate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ammonium Glycyrrhizinate图片
CAS NO:1407-03-0
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)839.96
FormulaC42H62O16.NH3
CAS No.1407-03-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 168 mg/mL (200.0 mM)
Water: 5 mg/mL (5.95 mM)
Ethanol: <1 mg/mL
SMILESC[C@]12[C@@](C(C=C3[C@]2(CC[C@]4(C)[C@@]3([H])C[C@](C(O)=O)(C)CC4)C)=O)([H])[C@@]5([C@@](C(C)([C@@H](O[C@]6([H])[C@@H]([C@H]([C@H](O)[C@@H](C(O)=O)O6)O)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O)=O)CC5)C)([H])CC1)C.N
SynonymsAMGZ, Glycyram; Monoammonium glycyrrhizinate
实验参考方法
In Vitro

In vitro activity: Ammonium glycyrrhizinate (AG) prepared from glycyrrhizin dramatically protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. AG also inhibits FeSO(4)-induced reactive oxygen radicals in a dose-dependent manner, suggesting the role for AG as a free radical scavenger.

In VivoAmmonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. Ammonium glycyrrhizinate-loaded nonionic surfactant vesicles (NSVs) decreases edema and nociceptive responses when compared with Ammonium glycyrrhizinate alone and empty NSVs in mice model. Ammonium glycyrrhizinate up-regulates interleukin-10 (IL-10) level and down-regulates the tumor neurosis factor-α (TNF-α) level and inhibits the cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) activity in the lung tissue of mice. Ammonium glycyrrhizinate -loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. Ammonium glycyrrhizinate significantly decreases triglyceride, cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels in rats. Ammonium glycyrrhizinate increases high density lipoprotein (HDL) levels increased in rats.
Animal modelMice and rats
Formulation & Dosage28 mg/kg
References

Exp Biol Med (Maywood). 2009 Mar;234(3):263-77; Eksp Klin Farmakol. 1997 Mar-Apr;60(2):65-7; Int J Nanomedicine. 2014 Jan 24;9:635-51.