Valiglurax (VU0652957; VU-2957; VU-0652957; VU2957) is a novel and potent mGlu4 positive allosteric modulator (PAM) with EC50 of 64.6 nM in calcium mobilization human mGlu4/Gqi5 assays. As a selective, CNS penetrant, and orally bioavailable mGlu4 PAM, VU2957 possessed excellent pharmacological and pharmacokinetic properties.

纯度：≥98%

CAS：1976050-09-5