VPS34-IN1 (VPS34-IN-1) is a novel and potent Vps34 (vacuolar protein sorting 34) inhibitor with potential antitumor activity. It inhibits Vps34 with an 25 nM IC50 and exhibits no activity against 350 closely related protein kinases or lipid kinases. The Vps34 class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a subset of proteins possessing PtdIns(3)P-binding PX (phox homology) and FYVE domains.

纯度：≥98%

CAS：1383716-33-3