Metoprine is a diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier. References: Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Takemura M. Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose. Drug Target Insights. 2016 Mar 2;10:1-7. doi: 10.4137/DTI.S38342. eCollection 2016. Review. PubMed PMID: 26966348; PubMed Central PMCID: PMC4777238.

纯度：≥98%

CAS：7761-45-7