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VU0400195
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1309434-83-0
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

VU0400195 is a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with orally bioavailable efficacy in an antiparkinsonian animal model. References: Jones CK, Engers DW, Thompson AD, Field JR, Blobaum AL, Lindsley SR, Zhou Y, Gogliotti RD, Jadhav S, Zamorano R, Bogenpohl J, Smith Y, Morrison R, Daniels JS, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. J Med Chem. 2011 Nov 10;54(21):7639-47. doi: 10.1021/jm200956q. Epub 2011 Oct 19. PubMed PMID: 21966889; PubMed Central PMCID: PMC3226828.

纯度:≥98%

CAS:1309434-83-0