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VU0467485
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1451994-10-7
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

VU0467485, formerly known as AZ13713945, is a potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulators (PAMs). VU0467485 represents a major advance in the field, as the first potent M4 PAM to overcome major species differences in potency while maintaining high selectivity versus M2 (rat, dog, cyno, and human EC50s > 30 μM), CNS penetration, and in vivo efficacy. VU0467485 showed robust efficacy in behaviorally bioavailable models that was evaluated as a preclinical candidate. References:

纯度:≥98%

CAS:1451994-10-7