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TIC10(imipridone,ONC201)HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TIC10(imipridone,ONC201)HCl图片
CAS NO:1638178-82-1
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

Description: TIC10 (imipridone, ONC-201) HCl is a novel, potent, orally bioactive, brain penetrant, and stable tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. TIC10 can inactivate Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. TIC10 is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10.

References:Cancer Res. 2015 Apr 15;75(8):1668-74; Sci Transl Med. 2013 Feb 6;5(171):171ra17.

Related CAS #:1616632-77-9 (free base); 1638178-82-1 (HCl); 41276-02-2 (TIC10 analog); 1777785-71-3 (HBr) 2007141-57-1 (2HBr) 41276-02-2 (TIC10 isomer)

纯度:≥98%

CAS:1638178-82-1