AGI-026 is a potent, selective inhibitor of the human IDH2R140Q-mutant enzyme. Differential expression of multiple genes and metabolites that are associated with cardiomyopathy were largely reversed by AGI-026 in Idh2R140Q mice. References: Wang F, Travins J, Lin Z, Si Y, Chen Y, Powe J, Murray S, Zhu D, Artin E, Gross S, Santiago S, Steadman M, Kernytsky A, Straley K, Lu C, Pop A, Struys EA, Jansen EE, Salomons GS, David MD, Quivoron C, Penard-Lacronique V, Regan KS, Liu W, Dang L, Yang H, Silverman L, Agresta S, Dorsch M, Biller S, Yen K, Cang Y, Su SM, Jin S. A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model. J Inherit Metab Dis. 2016 Nov;39(6):807-820. Epub 2016 Jul 28. PubMed PMID: 27469509; PubMed Central PMCID:PMC5065612.

纯度：≥98%

CAS：1446501-77-4