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8-Bromo-cAMP
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
8-Bromo-cAMP图片
CAS NO:76939-46-3
规格:≥98%
包装与价格：
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)430.08
FormulaC10H10BrN5NaO6P
CAS No.76939-46-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 80 mg/mL (186.01 mM)
Water: < 1 mg/mL
Ethanol: 35 mg/mL (81.38 mM)
Other info

Chemical Name: sodium (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide

InChi Key: DMRMZQATXPQOTP-GWTDSMLYSA-M

InChi Code: InChI=1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1

SMILES Code: O[C@H]1[C@@H](O[C@H]2[C@H]1OP(OC2)([O-])=O)N3C(Br)=NC4=C3N=CN=C4N.[Na+]

Synonyms

8 Br cAMP Na; 8BrcAMP sodium; 8-Br-cAMP Na

实验参考方法
In Vitro

In vitro activity: 8-Bromo-cAMP improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. In bronchial epithelial cells, 8-Bromo-cAMP decreases HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE; ADAM-17) activity and subsequent TNF-α release.

Cell Assay: 8-Bromo-cAMP increased the cellular content of mRNA encoding the hCG a- and β-subunits and prevented the increase in fibronectin mRNA. This is determined by blot hybridization analysis using specific cDNA probes. 8-Bromo-cAMP also induced phosphorylation of Erk1,2 in AML193 cells. 8-Bromo-cAMP is an agent in AML193 cells and activates Erk1,2 , this condition happens does not accompanied by the involvement of Shc phosphorylation.

In Vivo
Animal model
Formulation & Dosage
References

Stem Cell Rev. 2011 Jun;7(2):331-41; Am J Physiol Lung Cell Mol Physiol. 2014 Oct 15;307(8):L643-51.