CAS NO: | 76939-46-3 |
规格: | ≥98% |
包装 | 价格(元) |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
1g | 电议 |
Molecular Weight (MW) | 430.08 |
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Formula | C10H10BrN5NaO6P |
CAS No. | 76939-46-3 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 80 mg/mL (186.01 mM) |
Water: < 1 mg/mL | |
Ethanol: 35 mg/mL (81.38 mM) | |
Other info | Chemical Name: sodium (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide InChi Key: DMRMZQATXPQOTP-GWTDSMLYSA-M InChi Code: InChI=1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1 SMILES Code: O[C@H]1[C@@H](O[C@H]2[C@H]1OP(OC2)([O-])=O)N3C(Br)=NC4=C3N=CN=C4N.[Na+] |
Synonyms | 8 Br cAMP Na; 8BrcAMP sodium; 8-Br-cAMP Na |
In Vitro | In vitro activity: 8-Bromo-cAMP improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. In bronchial epithelial cells, 8-Bromo-cAMP decreases HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE; ADAM-17) activity and subsequent TNF-α release. Cell Assay: 8-Bromo-cAMP increased the cellular content of mRNA encoding the hCG a- and β-subunits and prevented the increase in fibronectin mRNA. This is determined by blot hybridization analysis using specific cDNA probes. 8-Bromo-cAMP also induced phosphorylation of Erk1,2 in AML193 cells. 8-Bromo-cAMP is an agent in AML193 cells and activates Erk1,2 , this condition happens does not accompanied by the involvement of Shc phosphorylation. |
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In Vivo | |
Animal model | |
Formulation & Dosage | |
References | Stem Cell Rev. 2011 Jun;7(2):331-41; Am J Physiol Lung Cell Mol Physiol. 2014 Oct 15;307(8):L643-51. |