Tretazicar (CB-1954; CB1954), a dinitrobenzamide analog and prodrug, is a potent and highly selective DNA alkylating agent that generates highly cytotoxic interstrand crosslinks in DNA. It is converted into a potent cytotoxic bifunctional DNA-alkylating agent in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP). CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino analogues, whereupon the non-enzymatic reaction of the 4-hydroxylamino analogue with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA.

纯度：≥98%

CAS：21919-05-1