生物活性

Erdosteine is a mucolytic which is used in treatment of excessive viscous mucus. Erdosteine belongs to a class of medicines called expectorants. Erdosteine is a homocysteine-derived expectorant which experiences metabolic conversion to produce a thiol containing compound that has free radical scavenging and mucolytic activity. Erdosteine is used for acute episodes of bronchitis where there is a buildup of sticky mucus in the chest. Specifically erdosteine is a thiol derivative developed for the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis. Erdosteine works by helping to break down mucus secretions. This helps to make mucus runnier and less sticky. This means that it is easier to clear the mucus from the chest. Erdosteine contains two blocked sulfhydryl groups which are released following first-pass metabolism. The three active metabolites exhibit mucolytic and free radical scavenging activity. Erdosteine regulates mucus production and viscosity and increases mucociliary transport, thereby improving expectoration. Erdosteine also reveals inhibitory activity against the effects of free radicals produced by cigarette smoke. Erdosteine significantly inhibited citric acid-induced cough reflexes in guinea-pigs but did not suppress mechanical stimuli-induced cough reflexes. On the other hand, erdosteine is associated with a low incidence of adverse events, most of which are gastrointestinal and generally mild. The LD50 of erdosteine is very high ranging from 3,500 to 5,000 mg/kg.

化学数据

不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

储备液配制

以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。