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Prednisone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Prednisone图片
CAS NO:53-03-2
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
2g电议
5g电议
10g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)358.43
FormulaC21H26O5
CAS No.53-03-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 71 mg/mL (198.1 mM)
Water:<1 mg/mL
Ethanol: <1 mg/mL
Other info
Chemical Name: (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
InChi Key: XOFYZVNMUHMLCC-ZPOLXVRWSA-N
InChi Code: InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
SMILES Code: CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C
SynonymsPrednisone; Dehydrocortisone; Deltasone; Meticorten; Decortin; Prednisonum; Deltasone; Encorton; Encortone; Enkortolon
实验参考方法
In Vitro

In vitro activity: Prednisone blocks Peripheral blood lymphocytes (PBL) growth in the G1 phase of cell cycle and inhibits both IL-2 receptor (IL-2R) expression and IL-2 secretion in activated human peripheral blood T lymphocytes. Prednisone increases apoptosis in PHA-activated human PBL, and the apoptotic effect of Prednisone is stronger on CD8(+) than on CD4(+) T lymphocytes.

In VivoPrednisone-treated rats show a significant delay of 20% in learning and memory retention in rats as compared with controls. Prednisone results in reduced weight gain, unchanged alter uterine weight, lowered serum magnesium (Mg), unchange serum calcium (Ca), phosphate (P), 25-hydroxyvitamin D (25OHD), or 1,25-dihydroxyvitamin D [1,25(OH)2D], striking increased in calcified cartilage, reduced cross-sectional area and cortical area, unchange medullary area of the tibial diaphysis, lowered periosteal and endocortical bone formation and apposition rates, increased mean cancellous bone area and cancellous bone perimeter of the tibial metaphysis in both sham-operated and ovariectomized rats. Prednisone-treated rabbit shows a 30% reduction in percent stenosis, a 35% decrease in neointimal area, and a 66% decrement in neointimal thickness. Prednisone treatment significantly reduces the level of TGF-beta1 and HYP in diaphragm from mdx mice to values similar to control mice, but results in a higher level of the HP cross-link compared with untreated mdx mice.
Animal modelRats
Formulation & DosageN/A
ReferencesClin Exp Immunol. 1996 Mar;103(3):482-90; J Investig Med. 2002 Nov;50(6):458-64.