Acitretin (also known as Etretin, RO 10-1670; Soriatane; Etretin; Neotigason) is a novel, potent, orally bioavailable, second generation retinoid used for psoriasis. Acitretin stimulates ADAM10 promoter activity with an EC50 of 1.5 mM and leads to an increase of mature ADAM10 protein that results in a two- to three-fold increase of the ratio between alpha- and beta-secretase activity in neuroblastoma cells. Acitretin (5-20 μM) impairs mitochondrial phosphorylation efficiency as demonstrated by the decrease in the state 3 respiration and ATP levels, and by the increase in the lag phase of ADP phosphorylation cycle, without affecting the membrane potential. Acitretin induces Ca(2+)-mediated mitochondrial permeability transition (MPT) and decreased the adenine nucleotide translocase (ANT) content.

纯度：≥98%

CAS：925701-88-8