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O4I2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
O4I2图片
CAS NO:165682-93-9
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
O4I2 (O-4I2; O4I-2; O-4I 2; O-4I2; O-4I-2; O4-I-2) is a novel and potent inducer of Oct3/4 (POU5F1 and Oct4).
理化性质和储存条件
Molecular Weight (MW)282.75
FormulaC12H11ClN2O2S
CAS No.165682-93-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 56 mg/mL (198.1 mM)
Water: <1 mg/mL
Ethanol: 20 mg/mL (70.7 mM)
Other info

Chemical Name: ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate

InChi Key: ULUBAPWNHROTEU-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H11ClN2O2S/c1-2-17-11(16)10-7-18-12(15-10)14-9-5-3-8(13)4-6-9/h3-7H,2H2,1H3,(H,14,15)

SMILES Code: O=C(C1=CSC(NC2=CC=C(Cl)C=C2)=N1)OCC

Synonyms

O4I2; O-4I2; O4I-2; O-4I 2; O-4I2; O-4I-2; O4-I-2

实验参考方法
In Vitro

In vitro activity: O4I2 activates Oct3/4 expression in HEK293 and embryonal NCCIT cells, and also in Oct-deficient HeLa and terminally differentiated human fibroblasts, and also induces other pluripotency-associated genes such as Lin28 and Nanog.

In Vivo
Animal model
Formulation & Dosage
References

J Med Chem. 2015 Aug 13;58(15):5742-50.