生物活性
Geniposidic acid is an effective anticancer and radioprotection agent. Geniposidic?acid might be a more potent tumor growth inhibitor than geniposide (GP) when combined with the X-irradiation, though there was no significant synergetic effect on their combined antitumor activity. In a study, collagen synthesis was stimulated by the administration of a hot water extract from the leaves of Eucommia ulmoides OLIVER, Eucommiaceae (Du-Zhong leaves) in false aged model rats. The administration of geniposidic?acid stimulated collagen synthesis in aged model rats.
化学数据
| 分子量 | 374.34 |
| 分子式 | C16H22O10 |
| CAS号 | 27741-01-1 |
| 纯度 | >98% |
| 溶解性（25°C） | DMSO 11 mg/mL |
| 储存和运输条件 | 固体粉末： -20°C 冷藏长期储存
常温运输及临时存放 |
实验操作 来自于公开的文献，仅供相同实验参考（如实验材料、目的不同，请参考其他文献）
| 细胞实验 |
|---|
| 细胞系 | Human umbilical vein ECs |
| 方法 | About 50 ml of geniposidic acid (25, 50, and 100 mg/ml) were added into each upper chamber of the Transwell chambers with two sub-wells for each dose group. They were cultured in an incubator thermostat with the condition of 5% CO2 and saturated humidity for 24 h. |
| 浓度 | 25, 50, and 100 mg/ml |
| 处理时间 | 24 h |
| 动物实验 |
|---|
| 动物模型 | Healthy male New Zealand rabbits |
| 配制 | water |
| 剂量 | 80, 160, and 240 mg/kg |
| 给药处理 | oral |
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。
储备液配制
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6714 mL | 13.3568 mL | 26.7137 mL |
| 5 mM | 0.5343 mL | 2.6714 mL | 5.3427 mL |
| 10 mM | 0.2671 mL | 1.3357 mL | 2.6714 mL |
m.cnreagent.com