A839977 (A-839977) is a novel and potent P2X7R antagonist with antihyperalgesic and anti-inflammatory activity. The pro-inflammatory cytokine interleukin-1beta (IL-1beta) has been implicated in both inflammatory processes and nociceptive neurotransmission. Activation of P2X7 receptors is the mechanism by which ATP stimulates the rapid maturation and release of IL-1beta from macrophages and microglial cells. Recently, selective P2X7 receptor antagonists have been shown to reduce inflammatory and neuropathic pain in animal models.

纯度：≥98%

CAS：870061-27-1