L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible (covalent) inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively. References: Fruehauf JP, et al. Selective and synergistic activity of L-S,R-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferase. Pigment Cell Res. 1997 Aug;10(4):236-49. [2]. Reliene R, et al. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis. 2006 Feb;27(2):240-4.

纯度：≥98%

CAS：83730-53-4