Pravastatin (CS514) is a potent HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. It is natural product isolated from cultures of Nocardia autotrophica. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.

纯度：≥98%

CAS：81093-37-0