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Picolinamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Picolinamide图片
CAS NO:1452-77-3
规格:≥98%
包装与价格:
包装价格(元)
1g电议
2g电议
5g电议
10g电议
25g电议
100g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)122.12
FormulaC6H6N2O
CAS No.1452-77-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 24 mg/mL (196.5 mM)
Water: 24 mg/mL (196.5 mM)
Ethanol: 24 mg/mL (196.5 mM)
Other infoSMILES: NC(=O)c1ccccn1

InChI: 1S/C6H6N2O/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9)

InChI key: IBBMAWULFFBRKK-UHFFFAOYSA-N

Synonyms2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine
实验参考方法
In Vitro

In vitro activity: Overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles. There is only a small increase (1.5-fold) in renal cortical NAD content after picolinamide treatment.


Cell Assay: The pathway of oxidation of picolinamide by a Gram-negative rod has been elucidated. Results showed that under high pH conditions, whole cells could release 2,5-dihydroxypyridine into culture supernatants. Moreover, sodium arsenite was able to cause whole cells to accumulate 6-hydroxypicolinate in the culture media. In addition, whole cells were found to oxidize picolinamide, without lag. It was also found that cell-free extracts could convert picolinamide into picolinate, and hydroxylate picolinate into 6-hydroxypicolinate.

In VivoPicolinamide was used in a previous study to evaluate the possibility that the inhibition of Na+/phosphate cotransport might be associated with the inhibition of NAD hydrolyzing enzymes. Results showed that the overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), could inhibit Na+/phosphate cotransport by isolated renal brush border membrane vesicles. Similar to nicotinamide, the inhibition caused by picolinamide occurred in thyroparathyroidectomized rats, was specific for Na+/phosphate cotransport. Unlike nicotinamide, there was only a small 1.5-fold increase in renal cortical NAD content after picolinamide treatment.
Animal modelWistar rats
Formulation & DosageDissolved in 0.9% NaCl solution; 250 mg/kg; i.p. injection
References

Cancer Res. 1985 Apr;45(4):1845-9; J Biol Chem. 1982 Jun 10;257(11):6084-8; J Pharmacol Exp Ther. 1989 Oct;251(1):188-92.