| CAS NO: | 485-35-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| Molecular Weight (MW) | 190.24 |
|---|---|
| Formula | C11H14N2O |
| CAS No. | 485-35-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 38 mg/mL (199.7 mM) |
| Water: 38 mg/mL (199.7 mM) | |
| Ethanol: 38 mg/mL (199.7 mM) | |
| Other info | Chemical Name: (1R,5S)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one InChi Key: ANJTVLIZGCUXLD-DTWKUNHWSA-N InChi Code: InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1 SMILES Code: O=C1C=CC=C2N1C[C@]3([H])CNC[C@@]2([H])C3 |
| Synonyms | Baphitoxine,Sophorine; Citizin; HSDB 3560; Laburnin; NSC 407282; NSC407282; HSDB3560; HSDB-3560; NSC-407282; Sophorin; Cytisine; Cytisinicline |
| In Vitro | In vitro activity: Cytisine, also known as baptitoxine, Cytisinicline and sophorine, is a naturally occuring alkaloid found in several plant genera, such as Laburnum and Cytisus of the family Fabaceae. It has been used medically to help with smoking cessation. Cytisine is a nicotinic acetylcholine receptor agonist. It isa potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Cell Assay: Cytisinicline (Cytisine) (2.5, 5 and 10 mM) is capable of inducing apoptosis in HepG2 cells. Treatment with Cytisinicline (Cytisine) increases the percentage of cells in the sub-G1 phase (P<0.01). The preincubation of HepG2 cells with Cytisinicline (Cytisine) (2.5, 5 and 10 mM) significantly increases the sub-G1 cell population. |
|---|---|
| In Vivo | Cytisinicline (Cytisine) (5 mg/kg, i.p.) eat less and gain less weight than those that receive the vehicle. Total pellet intake increases during Cytisinicline (Cytisine) substitution relative to nicotine and animals self-administered Cytisine significantly less than nicotine. |
| Animal model | N/A |
| Formulation & Dosage | 5 mg/kg, i.p. |
| References | [1]. Pabreza LA, et al. [3H]cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol. 1991 Jan;39(1):9-12. [2]. Grebenstein PE, et al. The effects of noncontingent and self-administered cytisine on body weight and meal patterns in male Sprague-Dawley rats. Pharmacol Biochem Behav. 2013 Sep;110:192-200. [3]. Walker N, et al. Cytisine versus nicotine for smoking cessation. N Engl J Med. 2014 Dec 18;371(25):2353-62. [4]. Yu L, et al. Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells. Oncol Rep. 2018 Mar;39(3):1475-1484. |
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