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P7C3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
P7C3图片
CAS NO:301353-96-8
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)474.19
FormulaC21H18Br2N2O
CAS No.301353-96-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 95 mg/mL (200.3 mM)
Water: <1 mg/mL
Ethanol: 20 mg/mL (42.2 mM)
SMILES Code OC(CNC1=CC=CC=C1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3
Synonyms P7C3; P7 C3; P 7C3
实验参考方法
In Vitro

In vitro activity: In U2OS Cells, P7C3 protects cells from doxorubicin-mediated toxicity, and enhances the flux of nicotinamide through the NAMPT-mediated salvage pathway.


Cell Assay: P7C3 (1, 10, and 100 nM) preserved mitochondrial membrane potential in parallel to proneurogenic activity. Administration of P7C3 (5 μM) to U2OS cells treated with doxorubicin, which induced NAD depletion, induced an increasing in intracellular NAD levels and concomitant protection from doxorubicin-mediated toxicity through the NAMPT-mediated salvage.

In VivoIn mouse brain, P7C3 (40 mg/kg, p.o.) induces neurogenesis and enhances survival of newborn neurons. In npas3–/– mice, P7C3 (20 mg/kg/d, p.o.) increases the magnitude of neural precursor cell proliferation, and corrects morphological and electrophysiological deficits. In the Ts65Dn mouse model of Down Syndrome, P7C3 restores hippocampal neurogenesis though a significant increase in total Ki67+, DCX+, and surviving BrdU+ cells.
Animal model Mouse
Formulation & DosageDissolved in DMSO and diluted with 3% DMSO/10% cremophor EL/87.5% D5W (5% dextrose in water, pH 7.2); 40 mg/kg; i.p. or oral administration
References

Cell. 2014 Sep 11;158(6):1324-34; Cell. 2010 Jul 9;142(1):39-51; Neurosci Lett. 2015 Mar 30;591:86-92.