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AR-A 014418
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AR-A 014418图片
CAS NO:487021-52-3
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
AR-A014418, ARA 014418, ARA014418
产品介绍

生物活性

AR-A 014418是一种选择性糖原合酶激酶3 (GSK-3) 抑制剂 (IC50 = 104 nM)。对GSK-3的特异性超过cdk2和cdk5(IC50值> 100μM)以及26种其他激酶。抑制β-淀粉样蛋白介导的海马片神经变性。

靶点信息

GSK-3β (Cell-free assay)GSK-3β (Cell-free assay)
38 nM(Ki)38 nM(Ki)

化学数据

目录号A13728
作用机制Inhibitor (抑制剂)
M. Wt308.31
FormulaC12H12N4O4S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.487021-52-3
SynonymsAR-A014418, ARA 014418, ARA014418
SMILESCOC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]

溶解度

In vitroDMSO55 mg/mL (178.39 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM32.43 mL162.17 mL324.35 mL
0.5 mM6.49 mL32.43 mL64.87 mL
1 mM3.24 mL16.22 mL32.43 mL
5 mM0.65 mL3.24 mL6.49 mL

*The above data is based on the productmolecular weight 308.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.