Dexmecamylamine, formerly known as TC-5214 and NIH-11008, is a nicotinic channel modulator with antidepressant activity. TC-5214 demonstrated positive effects in a number of animal models of depression and anxiety. TC-5214 was active in the forced swim test in rats (minimum effective dose (MED)=3 mg/kg i.p.), a classical depression model. It was also active in the behaviorally bioavailable despair test in mice (0.1-3.0 mg/kg i.p.), another model of depression. References: Zhao HP, Xiang BR. Discontinued cardiovascular drugs in 2013 and 2014. Expert Opin Investig Drugs. 2015;24(8):1083-92. doi: 10.1517/13543784.2015.1051619. PubMed PMID: 26162717.

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CAS：107596-30-5