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FAAH-IN-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FAAH-IN-2图片
CAS NO:184475-71-6
规格:≥98%
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议
2g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 319.72
Formula C15H11ClFN3O2
CAS No. 184475-71-6
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO:>20 mg/mL
Water: N/A
Ethanol: N/A
Chemical Name4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol; 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol
SynonymsFAAH-IN-2; O-Desmorpholinopropyl Gefitinib; JLVTVCRXFMLUIF-UHFFFAOYSA-N

InChi Key: JLVTVCRXFMLUIF-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H11ClFN3O2/c1-22-14-6-12-9(5-13(14)21)15(19-7-18-12)20-8-2-3-11(17)10(16)4-8/h2-7,21H,1H3,(H,18,19,20)

SMILES Code COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)O
实验参考方法
In Vitro

In vitro activity: FAAH-IN-2 is a novel and potent FAAH (fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2. It is also named as O-Desmorpholinopropyl Gefitinib and is a metabolite of gefitinib, which is an EGFR inhibitor. FAAHs (also known as EC 3.5.1.99, oleamide hydrolase, anandamide amidohydrolase) are a family of enzymes that belong to serine hydrolases. In humans, the family is represented by FAAH 1 and 2. It was first shown to break down anandamide in 1993. In humans, it is encoded by the gene FAAH.

In Vivo
Animal model
Formulation & Dosage
ReferencesJ Thorac Oncol. 2018 Oct;13(10):e211-e214; WO/2008/100977A2.