| CAS NO: | 13492-01-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 182.23 |
|---|---|
| Formula | C9H12NO2S0.5 |
| CAS No. | 13492-01-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 5 mg/mL |
| Water: 46.66 mg/mL | |
| Ethanol: | |
| Solubility (In vivo) | |
| Synonyms | Tranylcypromine, Parnate, d-Tranylcypromine, Transamine |
| In Vitro | In vitro activity: R-(+)-Tranylcypromine, (±)-Tranylcypromine, and S-(–)-Tranylcypromine competitively inhibits CYP2A6-mediated metabolism of nicotine with apparent Ki values of 0.05 μM, 0.08 μM, and 2.0 μM, respectively, in human liver microsomes. Tranylcypromine (500 μg/mL) severely inhibits bradykinin-stimulated arachidonic acid release in calf aortic endothelial cells. Tranylcypromine inhibits CYP2A6 and CYP2E1 activity with IC50 of 0.42 μM and 3 μM, respectively, in human liver microsomes. Tranylcypromine induces type II and cyclopropylbenzene type I difference spectrum in human liver microsomes. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Tranylcypromine injection leads to a large, slow increase in motor activity at 5 mg/kg and 10 mg/kg compared with the saline control in male rats, although 2 mg/kg Tranylcypromine does not induce an increase. Tranylcypromine (10 mg/kg) also causes significant decreases in the number of rearing behaviors in male rats. |
| Animal model | |
| Formulation & Dosage | |
| References | Drug Metab Dispos. 2001 Jun;29(6):897-902; Environ Health Perspect. 2004 Aug;112(11):1159-64. |
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