PI-103 Hydrochloride (PI 103; PI103), the hydrochloride salt of PI-103, is a multi-targeted PI3K and mTOR inhibitor with potential antineoplastic activity. It inhibits p110α/β/δ/γ with IC50s of 2 nM/3 nM/3 nM/15 nM in cell-free assays, and is less potent against mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 shows potent anti-proliferative activity in vitro against various cancer cell lines such as prostate, ovary and glioblastoma. It exerted antiproliferative GI50 values of 0.14, 0.06, 0.13, 0.10, 0.12 and 0.08 μM against U87MG, IGROV-1, DETROIT-562, PC3, SKOV-3 and HUVEC cells, respectively.

纯度：≥98%

CAS：371935-79-4