Description: LDN193189 3HCl (LDN-193189; DM-3189), the trihydrochloride salt of LDN193189, is a highly potent and selective inhibitor of the BMP (bone morphogenetic protein) signaling pathway with potential anticancer activity. LDN-193189 also exhibits inhibitory effects on associated vascular inflammation, osteogenic activity, and calcification. It inhibits the transcriptional activity of the BMP type I receptor kinases such as ALK2 (activin receptor-like kinase-2) and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cells, respectively.

References: Nat Med. 2008 Dec;14(12):1363-9; Br J Pharmacol. 2010 Sep;161(1):140-9.