EGFR-IN-5 is a novel and potent EGFR-TKI with potential anticancer effects. It inhibit the tyrosine kinases EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S with IC50s of 10.4, 1.1, 34, 7.2 nM, respectively. In vitro, it dose-dependently suppressed EGFR phosphorylation in HCC827 cells and induced the apoptosis of HCC827 cells.

纯度：≥98%

CAS：2225887-26-1