ADU-S100 ammonium salt (ADUS100; ML RR-S2 CDA; MIW815) is potent STING agonist with anticancer and immunomodulatory activities. STING (stimulator of interferon genes) signaling pathway has attracted considerable attention in cancer immunotherapy due to its capacity to boost vigorous antitumor immunity. ADU-S100 leads to potent and systemic tumor regression and immunity. ADU-S100 has the potential to be used in cancer immunotherapy. It elicits potent and durable anti-tumor immunity when administered intratumorally in pre-clinical syngeneic tumor models. As of 2018, it has entered phase I clinical trials for the treatment of cancer. Clinical candidate STING agonist ADU-S100 (S100) is used in an intratumoral dosing regimen optimized for adaptive immunity to uncover requirements for a T cell-driven response compatible with checkpoint inhibitors (CPIs).

纯度：≥98%

CAS：1638750-96-5