Description: Pyridostatin (RR82) is a G-quadruplexe (G4) stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2. Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC.

References: Nat Chem Biol. 2012 Feb 5;8(3):301-10; Nat Chem Biol. 2014 May;10(5):358-64.

Related CAS#: 1085412-37-8 (free base); 1472611-44-1 (TFA); 1629261-49-9 (HCl)

纯度：≥98%

CAS： 1085412-37-8