您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Donafenib(Sorafenib D3 Bay-43-9006 D3 CM4307)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Donafenib(Sorafenib D3 Bay-43-9006 D3 CM4307)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Donafenib(Sorafenib D3 Bay-43-9006 D3 CM4307)图片
CAS NO:1130115-44-4
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议

产品介绍

Donafenib (Sorafenib D3; Bay 43-9006 D3; CM-4307; Zepsun), the tri-deuterated (terminal CD3) form of Sorafenib, is a novel, potent and orally bioavailable multikinase inhibitor that has been approved in China (in 2021) for clinical uses to treat patients with unresectable hapatic tumors. It inhibits Raf kinase and receptor tyrosine kinases with potential anticancer acivity. Donafenib was under clinical trials in China in patients with advanced hepatocellular carcinoma (HCC). Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

纯度:≥98%

CAS:1130115-44-4