TMPyP4 tosylate, Telomerase inhibitor 是端粒酶抑制剂 (IC50 = 6.5 µM)。结合并稳定 DNA G 四链体,导致端粒酶抑制。 TMPyP4 tosylate 也显示出抗肿瘤作用。
中文别名 | TMPyP[=α,β,γ,δ-四(1-甲基吡啶嗡-4-基)卟吩对甲苯磺酸盐]; |
英文别名 | TMPyP4 tosylate, Telomerase inhibitor;Binds and stabilizes DNA G-quadruplexes.;TMPyP [=alpha,beta,gamma,delta-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate][Ultra-high sensitive spectrophotometric reagent for Cu, Mg] [For the simultaneous determination of metals: |
CAS号 | 36951-72-1 |
SMILES | C[n+]1ccc(cc1)/c/2c\3/nc(/c(c/4\[nH]/c(c(\c5n/c(c(\c6[nH]c2cc6)/c7cc[n+](cc7)C)/C=C5)/c8cc[n+](cc8)C)/cc4)/c9cc[n+](cc9)C)C=C3 |
Inchi | InChI=1S/C44H37N8/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31/h5-28H,1-4H3,(H,45,46,47,48)/q+3/p+1/b41-33-,41-34-,42-35-,42-37-,43-36-,43-38-,44-39-,44-40- |
InchiKey | ABCGFHPGHXSVKI-LWQDQPMZSA-O |
分子式 Formula | C72H66N8O12S4 |
分子量 Molecular Weight | 1364 |
性状 | Solid power |
储藏条件 Storage conditions | storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years) |