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Levetiracetam(UCB-L 059,SIB-S 1)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Levetiracetam(UCB-L 059,SIB-S 1)图片
CAS NO:102767-28-2
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)170.21
FormulaC8H14N2O2
CAS No.102767-28-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 34 mg/mL (199.8 mM)
Water: 34 mg/mL (199.8 mM)
Ethanol: 34 mg/mL (199.8 mM)
Solubility (In vivo)Saline: 30 mg/mL
Synonyms Levetiracetam, UCBL059, UCB L059, UCB-L059, SIB S1, SIBS1, SIB-S1, Keppra, Etiracetam, UCB6474, UCB-6474,

UCB 6474,

Chemical Name: (S)-2-(2-oxopyrrolidin-1-yl)butanamide

InChi Key: HPHUVLMMVZITSG-LURJTMIESA-N

InChi Code: InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1

SMILES Code: O=C(N)[C@H](CC)N1C(CCC1)=O

实验参考方法
In Vitro

In vitro activity: Levetiracetam and related compounds bind to SV2A expressed in fibroblasts, indicating that SV2A is sufficient for Levetiracetam binding. Levetiracetam irreversibly inhibits the high-voltage-activated (HVA) calcium current by approximately 18% on the average in freshly isolated CA1 hippocampal neurons of rats. Levetiracetam selectively inhibits N-type Ca2+ channels of CA1 pyramidal hippocampal neurons. Levetiracetam reverses the inhibitory effect of DMCM on GABA-elicited currents in hippocampal neurons

In VivoLevetiracetam (17 mg/kg) produces a potent suppression of sound-induced clonic convulsions in mice, and this protective effect is significantly abolished by co-administration of the beta-carboline FG 7142. Levetiracetam exerts potent anticonvulsant activity against both focal and secondarily generalized seizures in fully amygdala-kindled rats, i.e. , a model of temporal lobe epilepsy. Levetiracetam (13 mg/kg, 27 mg/kg or 54 mg/kg, i.p.) dose-dependently suppresses the increase in seizure severity and duration induced by repeated amygdala stimulation. Levetiracetam has a relatively short half-life (about 2-3 hours) in rats. Levetiracetam (5.4 mg/kg to 96 mg/kg i.p.) dose-dependently inhibits both wild running and tonic-clonic convulsions in the audiogenic-seizure prone rat. Levetiracetam markedly suppresses spontaneous spike-and-wave discharge (SWD) but leaves the underlying EEG trace normal in the GAERS model of petit mal epilepsy.
Animal modelMice
Formulation & Dosage5.4 mg/kg to 96 mg/kg i.p
References

Nature. 2005 May 26;435(7041):519-22; Br J Pharmacol. 2002 Jul;136(5):659-72.