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3α-Hydroxy pravastatin sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3α-Hydroxy pravastatin sodium图片
CAS NO:81093-43-8
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议

产品介绍
3α-Hydroxy pravastatin sodium is a major metabolite of the lipid-lowering drug Pravastatin. Pravastatin is an HMG-CoA reductase
inhibitor against sterol synthesis with IC50 of 5.6 μM. It is natural
product isolated from cultures of Nocardia autotrophica. Pravastatin
competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A
reductase, the enzyme which catalyzes the conversion of HMG-CoA to
mevalonate, a key step in cholesterol synthesis. This agent lowers
plasma cholesterol and lipoprotein levels, and modulates immune
responses by suppressing MHC II on interferon gamma-stimulated,
antigen-presenting cells such as human vascular endothelial cells.