Bitopertin (Paliflutine; RG1678; RO4917838; RG-1678; RO-4917838) is a novel, potent and non-competitive glycine reuptake inhibitor that inhibits human GlyT1 with an IC50 of 25 nM. GlyT1 is a key membrane transporter required to supply developing red blood cells with sufficient glycine to support erythropoiesis. It is under development as an adjunct to antipsychotics for the treatment of persistent negative symptoms or suboptimally-controlled positive symptoms associated with schizophrenia. Bitopertin-mediated glycine reuptake inhibition may represent a novel treatment option for schizophrenia, with the potential to address negative symptoms.

纯度：≥98%

CAS：845614-11-1