| CAS NO: | 2227372-56-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
Description: Loreclezole HCl (R72063; R72063; R 72063) is the hydrochloride salt of Loreclezole which is a triazole derivative and an anti-seizure, anticonvulsant and antiepileptic agent. Loreclezole acts as a subtype-selective positive allosteric modulator (PAM) of GABAA receptor. References: [1]. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73. [2]. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60. [3]. A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor. Neuropharmacology. 1996;35(9-10):1243-50. [4]. Loreclezole inhibition of recombinant alpha1beta1gamma2L GABA(A) receptor single channel currents. Neuropharmacology. 2000 Jan 4;39(2):235-45. Related CAS #: 117857-45-1 (free base) 2227372-56-5 (HCl)
纯度：≥98%
CAS：2227372-56-5
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