DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

1255942-08-5

C29H37N3O6

523.62

DBCO-NHCO-PEG4-amine

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years