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MEN 10376
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MEN 10376图片
CAS NO:135306-85-3
包装:5 mg
市场价:7000元

产品名称
Neurokinin-2 receptor antagonist
产品介绍

产品描述

Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.

体外活性

Men 10376 is a selective tachykinin NK-2 receptor (Ki: 4.4 μM). Men 10376 displays no effect on NK-3 receptor (Ki, >10 μM). It also displays low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). [2].

体内活性

Men 10376 (1 and 3 μmol/kg; in rats) antagonizes an enhance in bladder motility produced by the NK-2 receptor agonist [2].

Cas No.

135306-85-3

分子式

C57H68N12O10

分子量

1081.22

别名

Neurokinin-2 receptor antagonist;Men 10376

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years