Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

77544-68-4

C13H20O6S

304.36

Tos-PEG3

DMSO:100 mg/mL (328.56 mM),Need ultrasonic and warming
H2O:10 mg/mL (32.86 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years