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Lamivudine(BCH-189)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lamivudine(BCH-189)图片
CAS NO:134678-17-4
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
25g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)229.26
FormulaC8H11N3O3S
CAS No.134678-17-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 46 mg/mL (200.6 mM)
Water: 46 mg/mL (200.6 mM)
Ethanol: <1 mg/mL
Other info
Chemical Name: 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
InChi Key: JTEGQNOMFQHVDC-NKWVEPMBSA-N
InChi Code: InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
SMILES Code: O=C1N=C(N)C=CN1[C@@H]2CS[C@H](CO)O2
SynonymsGR109714X; BCH189; GR 109714X; BCH 189; GR-109714X; BCH-189; 3TC; Epivir, Zeffix, Heptovir
实验参考方法
In Vitro

In vitro activity: Lamivudine’s anti- HBV activity, like its anti-HIV activity, has been shown to depend on the ability of LMV-TP to serve as both substrate and inhibitor of the DNA- and RNA-dependent polymerase activities of the HBV P gene product. Lamivudine owes its activity to the remarkably broad substrate specificity of deoxycytidine kinase and the unusual substrate preference of the HBV polymerases for dNTPs with the unnatural L-conformation, whereas the anti-HBV activity of PCV appears to depend on several factors including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity) by key cellular enzymes, the long intracellular half-life of PCV-TP and the ability of PCV-TP to inhibit the HBV RT priming reaction as well as RT and DNA polymerase activity. Lamivudine and Penciclovir inhibits duck hepatitis B virus (DHBV) replication to a comparable extent when used alone, and in combination, the two nucleoside analogs acts synergistically over a wide range of clinically relevant concentrations. Lamivudine combined with Penciclovir is more effective in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV than either drug alone. Lamivudine inhibits p24 antigen production by HIV-I in PBMC, with ED50s ranging from 0.07 μM to 0.2 μM.

In Vivo
Animal model
Formulation & Dosage
ReferencesJ Viral Hepat. 1999 Mar;6(2):89-106; Hepatology. 1997 Jul;26(1):216-25.