OCTenidine dihydrochloride是一种防腐化合物，可用于皮肤粘膜和伤口。

Octenidine is an antibiosis.

Octenidine concentrations of less than1.5 μM (0.94 μg/mL) causes a greater than 99% reduction of tested microbial population within 15 min. Staphylococcus epidermidis is the most susceptible of the test organisms while E. coli and C. Albicans are the least susceptible[1].

The antimicrobial activity of octenidine hydrochloride (OCT) is maintained when applied to the skin of the hands and feet of cynomolgus monkeys. Aqueous octenidine reduces resident microflora populations from 90 to 99.98% at a concentration of 0.2 to 1.6%[1]. A significant reduction in plaque score is observed on the buccal tooth surfaces after daily topical application of 1% solutions of octenidine and chlorhexidine for 7 d; octenidine is more effective than chlorhexidine[2].

The bactericidal activities of OCT and CHG against Staphylococcus aureus are measured by exposing cultures to several different concentrations of each compound for various lengths of time. OCT is diluted from the 5 mM stock solution and tested in phosphate buffer at levels ranging from 0.5 to 5.0 FsM. The test is begun by adding the bacterial culture to the test solution containing OCT or CHG; samples are taken at 5, 15, 30, and 60 min afterward. The inoculum size is approximately 106 CFU/mL[1].

70775-75-6

C36H64Cl2N4

623.82

奥替尼啶;奥替尼啶双盐酸盐;Octenidine Dihydrochloride

DMSO:55 mg/mL(88.2 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years