SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating antagonist of β3-adrenergic receptor(IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively).

In Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines,SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner [3].

Slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post-injection produced by MDMA (20 mg/kg) . SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA[4].

1135278-41-9

C21H28ClNO2

361.91

SR59230A hydrochloride

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years