Amperozide 是一种 5-HT2 拮抗剂，可减轻大鼠对可卡因的渴望，并减少猪的激动行为，例如割伤和咬伤。

Amperozide, a 5-HT2 antagonist, attenuates craving for cocaine by rats and reduces agonistic behaviors such as slashing and biting in pigs.

Amperozide inhibited the amphetamine-stimulated release of dopamine from perfused rat striatal tissue in a dose-dependent manner. With 1 and 10 microM amperozide there was significant inhibition of the amphetamine-stimulated release of dopamine, to 44 and 36% of control. In contrast, 10 microM amperozide significantly strengthened the electrically stimulated release of dopamine from perfused striatal slices. Amperozide 1-10 microM had no significant effect on the potassium-stimulated release of dopamine. 10 microM amperozide also slightly increased the basal release of 3H-dopamine from perfused striatal tissue[1].

75558-90-6

C23H29F2N3O

401.49

Amperozidum;FG 5606;Amperozida;安哌齐持;Amperozide

DMSO:40 mg/ml (99.63 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years