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(±)16(17)-EpDPA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)16(17)-EpDPA图片
CAS NO:155073-46-4
包装与价格:
包装价格(元)
25 μg电议
50 μg电议
100 μg电议
500 μg电议
1 mg电议

产品名称
(±)16,17 EDP
(±)16,17-EpDPE
(±)16,17-epoxy Docosapentaenoic Acid
(±)16,17-epoxy DPA
产品介绍

产品描述

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA. The EDHF activity of (±)16(17)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.[4]

Cas No.

155073-46-4

分子式

C22H32O3

分子量

344.49

别名

(±)16,17 EDP;(±)16,17-EpDPE;(±)16,17-epoxy Docosapentaenoic Acid;(±)16(17)-EpDPA;(±)16,17-epoxy DPA;(±)16(17)-EpDPA

储存和溶解度

DMSO:50 mg/mL
DMF:50 mg/mL
PBS (pH 7.2):1 mg/mL
Ethanol:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years