Apoptotic agent-2 (compound 14b) 通过下调 BCL-2 和上调 Bax 和 Caspase-3 诱导细胞凋亡 (Apoptosis)。Apoptotic agent-2 具有抗增殖活性，可用于癌症研究。

Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research [1].

Apoptotic agent-2 (compound 14b) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2, MCF-7 and WI-38 (normal human cells) cells with IC 50 values of 1.96, 1.12, 2.38 and 107.5 μM, respectively [1]. Apoptotic agent-2 (compound 14b) (1.12 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 10.92 folds and 9.7 folds, respectively, and decreases the level of Bcl-2 by 3.3 folds [1]. Cell Cycle Analysis [1] Cell Line: HepG-2 cells Concentration: 1.12 μM Incubation Time: 24 hours Result: The percentage of cells in the G2-M phase increased while the percentage of cells in G0-G1 phase and S phase decreased. Apoptosis Analysis [1] Cell Line: HepG-2 cells Concentration: 1.12 μM Incubation Time: 24 hours Result: Increased the early apoptosis ratio from 0.69% to 5.17% and increased the late apoptosis ratio from 0.32% to 12.11%.

2482310-18-7

C25H16ClN7S

481.96

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years