ESI-08 is a highly potent and specific EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 specificly blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation. References: [1]. Chen H, et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.

纯度：≥98%

CAS：301177-43-5