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GSK656 HCl(2131798-13-3 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK656 HCl(2131798-13-3 free base)图片
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品名称
GSK 3036656
GSK656
GSK3036656
GSK 656
GSK-656
GSK656 HCl
GSK-3036656
GSK656 HCl (2131798-13-3 free base)
产品介绍

产品描述

GSK656 is a potent Mtb LeuRS inhibitor. GSK656 shows potent inhibition of Mtb LeuRS (IC50 = 0.20 μM) and in vitro antitubercular activity (Mtb H37Rv MIC = 0.08 μM). Additionally, it is highly selective for the Mtb LeuRS enzyme with IC50 of >300 μM and 132 μM for human mitochondrial LeuRS and human cytoplasmic LeuRS, respectively. In addition, it exhibits remarkable PK profiles and efficacy against Mtb in mouse TB infection models with superior tolerability over initial leads. GSK656 has been progressed to clinical development for the treatment of tuberculosis.

Cas No.

T27487

分子式

C10H14BCl2NO4

分子量

293.94

别名

GSK 3036656;GSK656;GSK3036656;GSK 656;GSK-656;GSK656 HCl;GSK-3036656;GSK656 HCl (2131798-13-3 free base)

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years