CMLD010509 (SDS-1-021) is a highly selective inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MDM2, CCND1, MYC, MAF, and MCL-1.

CMLD010509 is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism. CMLD010509 shows an IC50 below 10 nM for most MM cell lines and induces apoptosis.

256497-58-2

C27H26BrNO7

556.4

SDS-1-021;CMLD010509

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years